What are you up to tomorrow afternoon?

What are you up to these days?

What are you up to this weekend? Not much, just pottering about at home.

What are you up to?

So what are you up to today, Tom?

What are you up to today?

What are you up to now?

Who are you and what are you up to?

What are you up to with Mary?

For God's sake, what are you up to now?