In the age of the Portuguese maritime expeditions, sailors were afflicted with the most diverse illnesses: malignant fevers, diarrhea, and the dreaded and frequent scurvy, resulting from a lack of vitamin C caused by malnutrition.

Tom is a malignant narcissist.

There are various types of tumors – some benign and some malignant.

Here, girt with steel, the foremost in the fight, / fierce Juno stands, the Scaean gates before, / and, mad with fury and malignant spite, / calls up her federate forces from the shore."

A certain amount of ambitiousness, before it reaches the malignant stage, can also be an engine for progress.

It was an odious face—crafty, vicious, malignant, with shifty, light-grey eyes and white lashes.

Is it malignant?

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Various types of tumors exist, both benign and malignant.

The tumor is malignant.