Human nature can't possibly be so despicable as to be based on the loathsome attitude that is neutrality.

Sami developed loathing for his family.

You're really loathsome!

I loathe Tom even more for what he has done to Mary.

Hence, loathed melancholy.

I had taken a loathing to my gentleman at first sight.

I loathe you.

The leader of the separatists is teaching his followers to loathe anyone who is not with their separatist group.

Heavenly ire / ne'er sent a pest more loathsome; ne'er were seen / worse plagues to issue from the Stygian mire.

Tom and Mary are loath to share any details of their private life.